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Article

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

Journal of the American Chemical Society - 25 Sept 2013

Wadsworth John M, Clarke David J, McMahon Stephen A, Lowther Jonathan P, Beattie Ashley E, Langridge-Smith Pat R R, Broughton Howard B, Dunn Teresa M, Naismith James H, Campopiano Dominic J

Abstract excerpt

Sphingolipids (SLs) are essential components of cellular membranes formed from the condensation of L-serine and a long-chain acyl thioester. This first step is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising therapeutic target....

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Identifiers

PMID: 23957439
DOI: 10.1021/ja4059876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23957439-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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