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Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.

Medical oncology (Northwood, London, England) - 1 Dec 2013

Liu Huai, Huang Pei-Yu, Tang Lin-Quan, Chen Qiu-Yan, Zhang Ying, Zhang Lu, Guo Ling, Luo Dong-Hua, Mo Hao-Yuan, Xiang Yan-Qun, Qiu Fang, Sun Rui, Chen Ming-Yuan, Hua Yi-Jun, Lv Xing, Wang Lin, Zhao Chong, Guo Xiang, Cao Ka-Jia, Qian Chao-Nan, Hong Ming-Huang, Mai Hai-Qiang

Abstract excerpt

To investigate the prognostic role of major matrix metalloproteinase (MMP) gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated with chemoradiotherapy. Four hundred twenty-one consecutive NPC patients were prospectively recruited. Two hundred patients were randomly selected as the training cohort, and the remaining 221 patients were the validation cohort. Twelve...

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PMID: 23955812
DOI: 10.1007/s12032-013-0685-6

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