Article
Association between CYP3A5 genotypes in graft liver and increase in tacrolimus biotransformation from steroid treatment in living-donor liver transplant patients.
Drug metabolism and pharmacokinetics - 1 Jan 2014
Hosohata Keiko, Uesugi Miwa, Hashi Sachiyo, Hosokawa Mio, Inui Ken-Ichi, Matsubara Kazuo, Ogawa Kohei, Fujimoto Yasuhiro, Kaido Toshimi, Uemoto Shinji, Masuda Satohiro
Abstract excerpt
We retrospectively examined whether cytochrome P450 (CYP) 3A5 genotypes are associated with high-dose steroid pulse treatment-induced functional gain of tacrolimus biotransformation in living-donor liver transplant patients. Concentrations of tacrolimus and its 3 primary metabolites, 13-O-demethyl tacrolimus (M-I), 31-O-demethyl tacrolimus (M-II), and 15-O-demethyl tacrolimus (M-III), were measured in trough...
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