Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms.

doi:10.1016/j.dmpk.2021.100407

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Article

Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms.

Drug metabolism and pharmacokinetics - 1 Oct 2021

Watari Shogo, Araki Motoo, Matsumoto Jun, Yoshinaga Kasumi, Sekito Takanori, Maruyama Yuki, Mitsui Yosuke, Sadahira Takuya, Kubota Risa, Nishimura Shingo, Wada Koichiro, Kobayashi Yasuyuki, Takeuchi Hidemi, Tanabe Katsuyuki, Kitagawa Masashi, Morinaga Hiroshi, Kitamura Shinji, Sugiyama Hitoshi, Ariyoshi Noritaka, Wada Jun, Watanabe Masami, Watanabe Toyohiko, Nasu Yasutomo

Abstract excerpt

We evaluated the impact of vonoprazan on blood concentrations of tacrolimus via a retrospective analysis of 52 renal transplant recipients who took tacrolimus and converted from rabeprazole to vonoprazan between August 2018 and September 2019. We compared tacrolimus trough levels upon conversion among groups that were classified based on cytochrome P450 (CYP) gene polymorphisms. CYP3A5 groups were heterozygous or...

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PMID: 34352707
DOI: 10.1016/j.dmpk.2021.100407

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