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Article

Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.

Annals of hematology - 1 Oct 2013

Ashraf Saquib, Noguera Nélida I, Di Giandomenico Jonny, Zaza Serena, Hasan Syed Khizer, Lo-Coco Francesco

Abstract excerpt

NADP-dependent enzyme isocitrate dehydrogenase (IDH) mutations, IDH1 and IDH2, have been described in acute myeloid leukemia (AML) using next generation sequencing approaches. IDH2 mutations are heterozygous; they alter a single arginine residue at position 140 or 172 and have distinct prognostic significance. The current detection methods of IDH2 mutations are laborious and time consuming as they require DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23949315
DOI: 10.1007/s00277-013-1868-0

Genes

IDH2
IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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