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Article

Old Cryptococcus neoformans Cells Contribute to Virulence in Chronic Cryptococcosis

14 Aug 2013

Abstract excerpt

UNLABELLED: Does cell age matter in virulence? The emergence of persister cells during chronic infections is critical for persistence of infection, but little is known how this occurs. Here, we demonstrate for the first time that the replicative age of the fungal pathogen Cryptococcus neoformans contributes to persistence during chronic meningoencephalitis. Generationally older C. neoformans cells are more...

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PMID: 23943761
DOI: 10.1128/mbio.00455-13

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