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Article

[Genetic marker of statin-induced rhabdomyolysis].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Feb 2011

Chiba Kan, Morimoto Kaori

Abstract excerpt

This review summarizes genetic factors predisposed to statin-induced rhabdomyolysis. The first genetic risk factor of statin myopathy uncovered by genome-wide analysis of single nucleotide polymorphisms was the common variant of SLCO1B1 gene. Analysis of 30000 genetic markers in 85 patients with myopathy induced by high-dose simvastatin showed a strong association with 521T>C polymorphism of SLCO1B1. Another...

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Source

Identifiers

PMID: 21297370
DOI: 10.1248/yakushi.131.247

Genes

ABCB1
ABCG2

Provenance

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