Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population.

doi:10.1371/journal.pone.0071231

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Article

Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population.

PloS one - 1 Jan 2013

Best Lyle G, Saxena Richa, Anderson Cindy M, Barnes Michael R, Hakonarson Hakon, Falcon Gilbert, Martin Candelaria, Castillo Berta Almoguera, Karumanchi Ananth, Keplin Kylie, Pearson Nichole, Lamb Felicia, Bercier Shellee, Keating Brendan J

Abstract excerpt

BACKGROUND: The etiology of pre-eclampsia (PE) is unknown; but it is accepted that normal pregnancy represents a distinctive challenge to the maternal immune system. C-reactive protein is a prominent component of the innate immune system; and we previously reported an association between PE and the CRP polymorphism, rs1205. Our aim was to explore the effects of additional CRP variants. The IBC (Cardiochip)...

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PMID: 23940726
DOI: 10.1371/journal.pone.0071231
PMCID: PMC3733916

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