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Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn 4401 Deletion

4 Apr 2017

Abstract excerpt

ABSTRACT The Klebsiella pneumoniae carbapenemase gene ( bla KPC ) is typically located within mobile transposon Tn 4401 . Enhanced KPC expression has been associated with deletions in the putative promoter region upstream of bla KPC . Illumina sequences from bla KPC -positive clinical isolates from a single institution were mapped to a Tn 4401 b reference sequence, which carries no deletions. The novel isoform Tn...

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PMID: 28373185
DOI: 10.1128/aac.00025-17

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