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Article

Impaired Complex-I Mitochondrial Biogenesis in Parkinson Disease Frontal Cortex

1 Jan 2012

Abstract excerpt

Parkinson's disease (PD) can include a progressive frontal lobe α-synucleinopathy with disability from cognitive decline and cortico-limbic dysregulation that may arise from bioenergetic impairments. We examined in PD frontal cortex regulation of mitochondrial biogenesis (mitobiogenesis) and its effects on Complex-I. We quantified expression of 33 nuclear genome (nDNA)-encoded and 7 mitochondrial genome...

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Identifiers

PMID: 23939409
DOI: 10.3233/jpd-2012-11074

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