Article
BRAF and KIT somatic mutations are present in amelanotic melanoma.
Melanoma research - 1 Oct 2013
Massi Daniela, Pinzani Pamela, Simi Lisa, Salvianti Francesca, De Giorgi Vincenzo, Pizzichetta Maria A, Mirri Francesco, Steffan Agostino, Orlando Claudio, Santucci Marco, Canzonieri Vincenzo
Abstract excerpt
The genotypic profile of rare amelanotic melanomas (AMs) has been poorly investigated, thus preventing either an accurate identification as a distinctive melanoma subtype or therapy stratification. Here, we investigated the presence of the BRAF(V600E) mutation by real-time quantitative PCR and KIT mutations (exons 11 and 17) by sequencing analysis in 33 AMs. AMs included 'truly' amelanotic lesions (n = 19), with...
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