Increasing HIV-1 non-B subtype primary infections in patients in France and effect of HIV subtypes on virological and immunological responses to combined antiretroviral therapy.

doi:10.1093/cid/cis999

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Increasing HIV-1 non-B subtype primary infections in patients in France and effect of HIV subtypes on virological and immunological responses to combined antiretroviral therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Mar 2013

Chaix Marie-Laure, Seng Remonie, Frange Pierre, Tran Laurent, Avettand-Fenoël Véronique, Ghosn Jade, Reynes Jacques, Yazdanpanah Yazdan, Raffi François, Goujard Cécile, Rouzioux Christine, Meyer Laurence

Abstract excerpt

BACKGROUND: To analyze the time trends of the viral subtype distributions according to gender, risk group, and geographical origin of the patients in 1128 primary human immunodeficiency virus type 1 infection (PHI), diagnosed in France (1996-2010). To study whether the viral diversity had an impact on the virological and immunological responses in patients initiating combined antiretroviral therapy (cART) soon...

Topics

Adult
Anti-Retroviral Agents
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Cluster Analysis
Female
France
Genetic Variation
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Infections

HIV Reverse Transcriptase

HIV-1

Humans

Male

Phylogeny

Sequence Analysis, DNA

Treatment Outcome

Viral Load

Source

Open in PubMed

Identifiers

PMID: 23223603
DOI: 10.1093/cid/cis999

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