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Article

Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans.

Journal of biochemistry - 1 Nov 2013

Takeuchi Tomoharu, Nemoto-Sasaki Yoko, Sugiura Ken-ichi, Arata Yoichiro, Kasai Ken-ichi

Abstract excerpt

LEC-1 is a major galectin in Caenorhabditis elegans and contains two carbohydrate recognition domains (CRDs), N-CRD and C-CRD. To determine the role of LEC-1, we examined the phenotypes of a mutant C. elegans strain lacking lec-1. We observed negligible differences in embryogenesis, morphogenesis and egg laying at 20 °C between the mutant and the wild-type. Furthermore, the life spans of the mutant and the...

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PMID: 23935187
DOI: 10.1093/jb/mvt074

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