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Article

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.

The Journal of biological chemistry - 11 Oct 2013

Liu Hebin, Thaker Youg Raj, Stagg Loren, Schneider Helga, Ladbury John E, Rudd Christopher E

Abstract excerpt

Despite the importance of the immune adaptor SLP-76 in T-cell immunity, it has been unclear whether SLP-76 directly self-associates to form higher order oligomers for T-cell activation. In this study, we show that SLP-76 self-associates in response to T-cell receptor ligation as mediated by the N-terminal sterile α motif (SAM) domain. SLP-76 co-precipitated alternately tagged SLP-76 in response to anti-CD3...

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Identifiers

PMID: 23935094
DOI: 10.1074/jbc.M112.424846
PMCID: PMC3795252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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