Article
Analysis and correction of crosstalk effects in pathway analysis.
Genome research - 1 Nov 2013
Donato Michele, Xu Zhonghui, Tomoiaga Alin, Granneman James G, Mackenzie Robert G, Bao Riyue, Than Nandor Gabor, Westfall Peter H, Romero Roberto, Draghici Sorin
Abstract excerpt
Identifying the pathways that are significantly impacted in a given condition is a crucial step in understanding the underlying biological phenomena. All approaches currently available for this purpose calculate a P-value that aims to quantify the significance of the involvement of each pathway in the given phenotype. These P-values were previously thought to be independent. Here we show that this is not the...
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