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Epithelial, mesenchymal and hybrid epithelial/mesenchymal phenotypes and their clinical relevance in cancer metastasis.

Expert reviews in molecular medicine - 21 Mar 2017

Garg Minal

Abstract excerpt

Cancer metastasis occurs through local invasion of circulating tumour cells (CTCs), intravasation, transportation to distant sites, and their extravasation followed by colonisation at secondary sites. Epithelial-mesenchymal transition (EMT) is a normal developmental phenomenon, but its aberrant activation confers tumour cells with enhanced cell motility, metastatic properties, resistant to therapies and cancer...

Topics

Animals
Biological Transport
Biomarkers
Cytokines
Epithelial-Mesenchymal Transition
Gene Knockdown Techniques
Genetic Association Studies
Humans
Inflammation Mediators
Neoplasm Metastasis
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplastic Stem Cells

Phenotype

Tumor Microenvironment

Source

Identifiers

PMID: 28322181
DOI: 10.1017/erm.2017.6

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