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Article

Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations.

The Journal of clinical endocrinology and metabolism - 1 Jun 2012

Loriot Céline, Burnichon Nelly, Gadessaud Noémie, Vescovo Laure, Amar Laurence, Libé Rossella, Bertherat Jérôme, Plouin Pierre-François, Jeunemaitre Xavier, Gimenez-Roqueplo Anne-Paule, Favier Judith

Abstract excerpt

CONTEXT: Pheochromocytoma and paraganglioma are rare neural-crest-derived tumors. They are metastatic in 15% of cases, and the identification of a germline mutation in the SDHB gene is a predictive risk factor for malignancy and poor prognosis. To date, the link between SDHB mutations and maligna...

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Source

Identifiers

PMID: 22492777
DOI: 10.1210/jc.2011-3437

Genes

SDHB
KRT19
LOXL2
MMP2
TCF3
CDH2
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22492777-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations.PMID 22492777Read ↗

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