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Article

Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.

Molecular cancer research : MCR - 1 Oct 2013

Gurung Buddha, Feng Zijie, Hua Xianxin

Abstract excerpt

UNLABELLED: Multiple endocrine neoplasia type 1 (MEN-1), is a familial tumor syndrome resulting from mutations in the tumor suppressor gene menin (MEN1). Menin plays an essential role in both repressing and activating gene expression. However, it is not well understood how menin represses expression of multiple genes. Upon MEN1 excision, the transcription factor Gli1 and its target genes, including Ptch1 and...

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Source

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Identifiers

PMID: 23928057
DOI: 10.1158/1541-7786.MCR-13-0170
PMCID: PMC4028077

Genes

MEN1
GLI1
PRMT5
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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