Article
The plant RABC1 GTPase coordinates with exocyst component SEC5A in regulating ER-phagy under endoplasmic reticulum stress.
The Plant cell - 2 Jul 2026
Hu Shuai, Zhu Dongmei, Ma Xiaohui, Shi Linjuan, Zhang Wenze, Huang Mei, Lin Youshun, Li Baiying, Zeng Yonglun, Jiang Liwen, Shen Jinbo
Abstract excerpt
Small GTPase proteins regulate intracellular transport between endomembrane compartments, yet their roles in endoplasmic reticulum (ER) stress responses and selective autophagy remain poorly understood. Here, we characterize the plant RAB GTPase RABC1 as a regulator of ER-phagy during ER stress. Our results demonstrate that rabc1 mutants are hypersensitive to heat shock and ER stress inducers dithiothreitol (DTT)...
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