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Article

Targeting the Wnt Pathway in Synovial Sarcoma Models

6 Aug 2013

Abstract excerpt

UNLABELLED: Synovial sarcoma is an aggressive soft-tissue malignancy of children and young adults, with no effective systemic therapies. Its specific oncogene, SYT-SSX (SS18-SSX), drives sarcoma initiation and development. The exact mechanism of SYT-SSX oncogenic function remains unknown. In an SYT-SSX2 transgenic model, we show that a constitutive Wnt/β-catenin signal is aberrantly activated by SYT-SSX2, and...

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PMID: 23921231
DOI: 10.1158/2159-8290.cd-13-0138

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