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Article

Androgen depletion up‐regulates cadherin‐11 expression in prostate cancer

15 Jan 2010

Abstract excerpt

Men with castration-resistant prostate cancer (PCa) frequently develop metastasis in bone. The reason for this association is unclear. We have previously shown that cadherin-11 (also known as OB-cadherin), a homophilic cell adhesion molecule that mediates osteoblast adhesion, plays a role in the metastasis of PCa to bone. Here, we report that androgen-deprivation therapy up-regulates cadherin-11 expression in...

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PMID: 20191612
DOI: 10.1002/path.2687

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