Article
Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling.
Circulation - 10 Sept 2013
Coelho-Filho Otavio R, Shah Ravi V, Mitchell Richard, Neilan Tomas G, Moreno Heitor, Simonson Bridget, Kwong Raymond, Rosenzweig Anthony, Das Saumya, Jerosch-Herold Michael
Abstract excerpt
BACKGROUND: Cardiomyocyte hypertrophy is a critical precursor to the development of heart failure. Methods to phenotype cellular hypertrophy noninvasively are limited. The goal was to validate a cardiac magnetic resonance-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. METHODS AND RESULTS: Two murine models of hypertension (n=18, with n=15 controls)...
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