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Article

Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.

Developmental biology - 1 Oct 2013

Crish James, Conti Mary Anne, Sakai Takao, Adelstein Robert S, Egelhoff Thomas T

Abstract excerpt

In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox/flox)) were crossed with the K5-Cre line. The progeny of newborn pups did not show a Mendelian...

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Identifiers

PMID: 23911870
DOI: 10.1016/j.ydbio.2013.07.017
PMCID: PMC4186751

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