Article
Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement.
Cancer genetics - 1 Jun 2013
Mackinnon Ruth N, Campbell Lynda J
Abstract excerpt
Chromothripsis is a recently described phenomenon identified in cancer cells that produces catastrophic chromosome reorganization of one or a small number of chromosomes. It has been proposed that the multiple breakage events occur at a single point in time. Here we introduce the term anachromosome to describe an abnormal chromosome produced by chromothripsis. We report two cases of acute myeloid leukemia...
Topics
- Adult
- Aged, 80 and over
- Chromosome Aberrations
- Cytogenetic Analysis
- Female
- Gene Deletion
- Gene Rearrangement
- Humans
- Leukemia, Myeloid, Acute
- Male
- Polymorphism, Single Nucleotide