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Article

Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis.

Human molecular genetics - 20 Dec 2013

Li Xin, Young Nathan M, Tropp Stephen, Hu Diane, Xu Yanhua, Hallgrímsson Benedikt, Marcucio Ralph S

Abstract excerpt

Fibroblast growth factor (FGF) signaling mutations are a frequent contributor to craniofacial malformations including midfacial anomalies and craniosynostosis. FGF signaling has been shown to control cellular mechanisms that contribute to facial morphogenesis and growth such as proliferation, survival, migration and differentiation. We hypothesized that FGF signaling not only controls the magnitude of growth...

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Identifiers

PMID: 23906837
DOI: 10.1093/hmg/ddt369
PMCID: PMC3842176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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