Article
Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila.
Molecular cell - 13 Jul 2012
Rodriguez Joseph, Menet Jerome S, Rosbash Michael
Abstract excerpt
The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila by isolating nascent RNA from adult fly heads and subjecting samples to high throughput sequencing. There are a large number of edited sites within nascent exons. Nascent RNA from an ADAR-null strain was also sequenced,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.