Article
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.
Cell - 18 Aug 2000
Palladino M J, Keegan L P, O'Connell M A, Reenan R A
Abstract excerpt
Specific A-to-I RNA editing, like that seen in mammals, has been reported for several Drosophila ion channel genes. Drosophila possesses a candidate editing enzyme, dADAR. Here, we describe dADAR deletion mutants that lack ADAR activity in extracts. Correspondingly, all known Drosophila site-specific RNA editing (25 sites in three ion channel transcripts) is abolished. Adults lacking dADAR are morphologically...
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