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Article

Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies.

AIDS research and human retroviruses - 1 Jul 1990

Haigwood N L, Shuster J R, Moore G K, Lee H, Skiles P V, Higgins K W, Barr P J, George-Nascimento C, Steimer K S

Abstract excerpt

Variants of the envelope gene of the HIV-SF2 isolate of HIV-1 with deletions of one or more of the hypervariable domains of gp120 were produced in genetically engineered yeast as nonglycosylated denatured polypeptide analogs of gp120. Purified antigens were used to immunize experimental animals to determine whether the removal of hypervariable regions from this type of gp120 immunogen had any effect on (1) the...

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Identifiers

PMID: 2390335
DOI: 10.1089/aid.1990.6.855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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