Article
Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies.
AIDS research and human retroviruses - 1 Jul 1990
Haigwood N L, Shuster J R, Moore G K, Lee H, Skiles P V, Higgins K W, Barr P J, George-Nascimento C, Steimer K S
Abstract excerpt
Variants of the envelope gene of the HIV-SF2 isolate of HIV-1 with deletions of one or more of the hypervariable domains of gp120 were produced in genetically engineered yeast as nonglycosylated denatured polypeptide analogs of gp120. Purified antigens were used to immunize experimental animals t...
Topics
- Animals
- Blotting, Western
- Cells, Cultured
- Female
- Guinea Pigs
- HIV Antibodies
- HIV Antigens
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Immunization
- Mutation
- Neutralization Tests
- Recombinant Proteins
- Vaccines, Synthetic
- Viral Vaccines