Article
Contribution of hypervariable domains to the conformation of a broadly neutralizing glycoprotein 120 epitope.
AIDS research and human retroviruses - 1 Jul 1995
Lee C N, Robinson J, Mazzara G, Cheng Y L, Essex M, Lee T H
Abstract excerpt
Three of the five hypervariable domains (V1-V3) of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 have previously been shown to be dispensable for antigenic epitopes recognized by broadly neutralizing monoclonal antibodies. In this study, the influence of the V4 and V5 do...
Topics
- Antibodies, Monoclonal
- Antigens, CD
- Base Sequence
- Binding Sites, Antibody
- CD4 Antigens
- Epitopes
- Genetic Variation
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Neutralization Tests
- Oligodeoxyribonucleotides
- Protein Conformation
- Recombinant Proteins
- Sequence Deletion