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Article

Contribution of hypervariable domains to the conformation of a broadly neutralizing glycoprotein 120 epitope.

AIDS research and human retroviruses - 1 Jul 1995

Lee C N, Robinson J, Mazzara G, Cheng Y L, Essex M, Lee T H

Abstract excerpt

Three of the five hypervariable domains (V1-V3) of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 have previously been shown to be dispensable for antigenic epitopes recognized by broadly neutralizing monoclonal antibodies. In this study, the influence of the V4 and V5 domains on an epitope recognized by a broadly neutralizing human monoclonal antibody, 1.5e, was investigated. In contrast...

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Identifiers

PMID: 7546903
DOI: 10.1089/aid.1995.11.777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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