Comparative immunogenicity of gp120-derived proteins and their induction of anti-V3 loop region antibodies.

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Article

Comparative immunogenicity of gp120-derived proteins and their induction of anti-V3 loop region antibodies.

Journal of acquired immune deficiency syndromes - 1 Oct 1992

Klinman D M, Steimer K S, Conover J

Abstract excerpt

This report compares the immunogenicity of three different preparations of gp120 [the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) virus]: (a) native, fully glycosylated gp120; (b) a nonglycosylated, denatured form of gp120; and (c) a nonglycosylated peptide representing the "immunodominant" third hypervariable region of the gp120 molecule. Results indicate that the native glycosylated...

Topics

Animals
Antibody Formation
B-Lymphocytes
CHO Cells
Cricetinae
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Epitopes
Female
Genetic Variation
Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Antibodies

HIV Envelope Protein gp120

HIV-1

Mice

Mice, Inbred BALB C

Protein Conformation

Protein Denaturation

Source

Open in PubMed

Identifiers

PMID: 1280682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1280682-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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