Article
Potent neutralization of primary HIV-1 isolates by antibodies directed against epitopes present in the V1/V2 domain of HIV-1 gp120.
Vaccine - 1 Nov 1998
Pinter A, Honnen W J, Kayman S C, Trochev O, Wu Z
Abstract excerpt
Although it is known that some human immune sera possess potent neutralizing activities for primary viruses, the identity of the target epitopes mediating this neutralization is unknown, and currently available immunogens have not been able to induce such activities. Using recombinant fusion glyc...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- CHO Cells
- Chromatography, Affinity
- Cricetinae
- Epitopes
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Molecular Sequence Data
- Neutralization Tests
- Phenotype
- Protein Structure, Tertiary
- Recombinant Fusion Proteins