Article
Antibodies against Manalpha1,2-Manalpha1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains.
Glycobiology - 1 Mar 2010
Luallen Robert J, Agrawal-Gamse Caroline, Fu Hu, Smith David F, Doms Robert W, Geng Yu
Abstract excerpt
Design of an envelope glycoprotein (Env)-based vaccine against human immunodeficiency virus type-1 (HIV-1) is complicated by the large number of N-linked glycans that coat the protein and serve as a barrier to antibody-mediated neutralization. Compared to normal mammalian glycoproteins, high-mann...
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