Article
Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates.
Acta crystallographica. Section D, Biological crystallography - 1 Aug 2013
Yu Keum Ran, Kim Young Jun, Jung Suk-Kyeong, Ku Bonsu, Park Hwangseo, Cho Sa Yeon, Jung Hyeyun, Chung Sang J, Bae Kwang Hee, Lee Sang Chul, Kim Bo Yeon, Erikson Raymond L, Ryu Seong Eon, Kim Seung Jun
Abstract excerpt
Unlike other classical protein tyrosine phosphatases (PTPs), PTPRQ (PTP receptor type Q) has dephosphorylating activity towards phosphatidylinositide (PI) substrates. Here, the structure of the catalytic domain of PTPRQ was solved at 1.56 Å resolution. Overall, PTPRQ adopts a tertiary fold typical of other classical PTPs. However, the disordered M6 loop of PTPRQ surrounding the catalytic core and the concomitant...
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