Article
Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo.
Hepatology (Baltimore, Md.) - 2 Sept 2011
Hiraga Nobuhiko, Imamura Michio, Abe Hiromi, Hayes C Nelson, Kono Tomohiko, Onishi Mayu, Tsuge Masataka, Takahashi Shoichi, Ochi Hidenori, Iwao Eiji, Kamiya Naohiro, Yamada Ichimaro, Tateno Chise, Yoshizato Katsutoshi, Matsui Hirotaka, Kanai Akinori, Inaba Toshiya, Tanaka Shinji, Chayama Kazuaki
Abstract excerpt
UNLABELLED: Telaprevir is a potent inhibitor of hepatitis C virus (HCV) NS3-4A protease. However, the emergence of drug-resistant strains during therapy is a serious problem, and the susceptibility of resistant strains to interferon (IFN), as well as the details of the emergence of mutant strains in vivo, is not known. We previously established an infectious model of HCV using human hepatocyte chimeric mice....
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