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Article

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation.

Microvascular research - 1 Nov 2011

Singh Seema, Wu Sheng, Varney Michelle, Singh Ajay P, Singh Rakesh K

Abstract excerpt

CXCR1 and CXCR2 are receptors for angiogenic ELR+CXC chemokines and are differentially expressed on endothelial cells; however, their functional significance in angiogenesis remains unclear. In this study, we determined the functional significance of these receptors in modulating endothelial cell...

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Share to Endothelial Cells
Share to Extracellular Signal-Regulated MAP Kinases
Share to Interleukin-8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

Share to Receptors, Interleukin-8A

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Source

Open in PubMed Open full text

Identifiers

PMID: 21749879
DOI: 10.1016/j.mvr.2011.06.011
PMCID: PMC3215896

Genes

CXCR1
CXCR2
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21749879-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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