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Article

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation.

Microvascular research - 1 Nov 2011

Singh Seema, Wu Sheng, Varney Michelle, Singh Ajay P, Singh Rakesh K

Abstract excerpt

CXCR1 and CXCR2 are receptors for angiogenic ELR+CXC chemokines and are differentially expressed on endothelial cells; however, their functional significance in angiogenesis remains unclear. In this study, we determined the functional significance of these receptors in modulating endothelial cell phenotype by knocking-down the expression of CXCR1 and/or CXCR2 in human microvascular endothelial cells (HMEC-1)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21749879
DOI: 10.1016/j.mvr.2011.06.011
PMCID: PMC3215896

Genes

CXCR1
CXCR2
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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