Article
Tumor site- and stage-specific associations between allelic variants of glutathione S-transferase and DNA-repair genes and overall survival in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy.
PloS one - 1 Jan 2013
Lai Ching-Yu, Hsieh Ling-Ling, Sung Fung-Chang, Tang Reiping, Bai Chyi-Huey, Wu Fang-Yang, Chiou Hung-Yi, Yeh Chih-Ching
Abstract excerpt
INTRODUCTION: Our retrospective cohort study investigated the effect of tumor site and stage on the associations between the allelic variants of glutathione S-transferase (GST) and DNA-repair genes and overall survival (OS) in CRC patients treated with 5-fluorouracil (5-FU)-based adjuvant chemotherapy. MATERIAL AND METHODS: We genotyped GSTM1, GSTT1, GSTP1 Ile105Val, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD...
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