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Article

Repeated PTZ treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats.

PloS one - 1 Jan 2012

Buga Ana-Maria, Vintilescu Raluca, Balseanu Adrian Tudor, Pop Oltin Tiberiu, Streba Costin, Toescu Emil, Popa-Wagner Aurel

Abstract excerpt

BACKGROUND: Neurogenesis persists throughout life in the adult mammalian brain. Because neurogenesis can only be assessed in postmortem tissue, its functional significance remains undetermined, and identifying an in vivo correlate of neurogenesis has become an important goal. By studying pentylenetetrazole-induced brain stimulation in a rat model of kindling we accidentally discovered that 25±1 days periodic...

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PMID: 22768071
DOI: 10.1371/journal.pone.0039302
PMCID: PMC3387140

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