Article
Peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: a study in Brazilian patients.
Gene - 25 Oct 2013
Domenici Fernanda Aparecida, Brochado Maria José Franco, Martinelli Ana de Lourdes Candolo, Zucoloto Sergio, da Cunha Selma Freire de Carvalho, Vannucchi Helio
Abstract excerpt
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis in the absence of excess alcohol consumption. The pathogenesis of fatty liver disease and steatohepatitis (NASH) is not fully elucidated, but the common association with visceral obesity, hyperlipidemia, hypertension and type 2 diabetes mellitus (T2DM) suggests that it is the hepatic manifestation of metabolic...
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