Article
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study.
BMC gastroenterology - 8 Sept 2010
Dongiovanni Paola, Rametta Raffaela, Fracanzani Anna Ludovica, Benedan Luca, Borroni Vittorio, Maggioni Paolo, Maggioni Marco, Fargion Silvia, Valenti Luca
Abstract excerpt
BACKGROUND: Peroxisome proliferator-activated receptors (PPARs) play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). AIM: to assess the effect of functional single nucleotide polymorphisms (SNPs) of PPARα and PPARγ2, previously associated with insulin resistance and dyslipidemia, on liver damage in NAFLD, whose progression is influenced by metabolic abnormalities and inherited factors....
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