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Article

Differentiation of Human Embryonic Stem Cells Into Functional Ovarian Granulosa-like Cells

25 Jul 2013

Abstract excerpt

CONTEXT: Granulosa cells are important for the development and maturation of oocytes. The dysfunction of granulosa cells may contribute to abnormal folliculogenesis and steroidogenesis. OBJECTIVE: Our objective was to establish an effective culture system to differentiate human embryonic stem cells (hESCs) into granulosa cells. DESIGN: For differentiation of hESCs to granulosa cells, we used multistep approaches...

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PMID: 23884780
DOI: 10.1210/jc.2012-4302

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