Article
Association of 49245A>G (rs868) polymorphism in the 3'UTR of donor TGFBR1 gene with course of hepatitis C following orthotopic liver transplantation.
Annals of transplantation - 12 Dec 2014
Ziarkiewicz-Wróblewska Bogna, Sajjad Emir, Ciszek Michał, Hutnik Łukasz, Łukasik Dominika, Fedorowicz Mikołaj, Wróblewski Tadeusz, Patkowski Waldemar, Pączek Leszek, Płoski Rafał, Włodarski Paweł, Malejczyk Jacek
Abstract excerpt
BACKGROUND: Terminal hepatitis C is one of the leading indications for orthotopic liver transplantation (OLT). However, hepatitis C virus (HCV) reinfection occurs in almost all recipients and usually leads to progressive fibrosis and graft failure. Transforming growth factor-b (TGF-β) plays a part in transplanted liver cirrhosis, but nothing is known about the possible role of genetic diversity of TGF-β receptor...
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