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Article

Neurodegenerative disorders: From clinicopathology convergence to systems biology divergence.

Handbook of clinical neurology - 1 Jan 2023

Fasano Mauro, Alberio Tiziana

Abstract excerpt

Neurodegenerative diseases are multifactorial. This means that several genetic, epigenetic, and environmental factors contribute to their emergence. Therefore, for the future management of these highly prevalent diseases, it is necessary to change perspective. If a holistic viewpoint is assumed, the phenotype (the clinicopathological convergence) emerges from the perturbation of a complex system of functional...

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PMID: 36796949
DOI: 10.1016/B978-0-323-85538-9.00007-9

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