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Article

Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF.

European biophysics journal : EBJ - 1 Dec 2006

Miedema Henk, Vrouenraets Maarten, Wierenga Jenny, Eisenberg Bob, Schirmer Tilman, Baslé Arnaud, Meijberg Wim

Abstract excerpt

A recent molecular dynamics study questioned the protonation state and physiological role of aspartate 127 (D127) of E. coli porin OmpF. To address that question we isolated two OmpF mutants with D127 either neutralized (D127N) or replaced by a positively charged lysine (D127K). The charge state of the residue at position 127 has clear effects on both conductance and selectivity. The D127K but not the D127N...

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Identifiers

PMID: 16858566
DOI: 10.1007/s00249-006-0084-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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