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Article

Mouse hepatic cells support assembly of infectious hepatitis C virus particles.

Gastroenterology - 1 Sept 2011

Long Gang, Hiet Marie-Sophie, Windisch Marc P, Lee Ji-Young, Lohmann Volker, Bartenschlager Ralf

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) has a high propensity to establish persistence; better understanding of this process requires the development of a fully permissive and immunocompetent small animal model. Mouse cells can be engineered to express the human orthologs of the entry molecules CD81 and occludin to allow entry of HCV. However, RNA replication is poor in mouse cells, and it is not clear whether...

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Source

Identifiers

PMID: 21699799
DOI: 10.1053/j.gastro.2011.06.010

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