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Article

The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML)

19 Jul 2013

Abstract excerpt

BACKGROUND: There is growing evidence supporting a role for microRNAs (miRNA) as targets in aberrant mechanisms of DNA hypermethylation. Epigenetic silencing of tumor suppressor miRNAs, including miR-663, which has recently been reported to be inactivated by hypermethylation in several cancers, may play important roles in pediatric acute myeloid leukemia (AML). However, expression of miR-663 and its promoter...

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PMID: 23870168
DOI: 10.1186/1471-2350-14-74

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