Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion.

doi:10.1111/bjh.12479

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Article

Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion.

British journal of haematology - 1 Oct 2013

Puiggros Anna, Delgado Julio, Rodriguez-Vicente Ana, Collado Rosa, Aventín Anna, Luño Elisa, Grau Javier, Hernandez José Ángel, Marugán Isabel, Ardanaz Maite, González Teresa, Valiente Alberto, Osma Mar, Calasanz Maria José, Sanzo Carmen, Carrió Ana, Ortega Margarita, Santacruz Rodrigo, Abrisqueta Pau, Abella Eugènia, Bosch Francesc, Carbonell Félix, Solé Francesc, Hernández Jesús Maria, Espinet Blanca

Abstract excerpt

Losses in 13q as a sole abnormality confer a good prognosis in chronic lymphocytic leukaemia (CLL). Nevertheless, its heterogeneity has been demonstrated and the clinical significance of biallelic 13q deletions remains controversial. We compared the clinico-biological characteristics of a series of 627 patients harbouring isolated 13q deletions by fluorescence in situ hybridization (FISH), either monoallelic (13q...

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PMID: 23869550
DOI: 10.1111/bjh.12479

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