Article
The prognostic difference of monoallelic versus biallelic deletion of 13q in chronic lymphocytic leukemia.
Cancer - 15 Jul 2012
Garg Ravin, Wierda William, Ferrajoli Alessandra, Abruzzo Lynne, Pierce Sherry, Lerner Susan, Keating Michael, O'Brien Susan
Abstract excerpt
BACKGROUND: Fluorescence in situ hybridization can detect genomic abnormalities in up to 80% of cases and provides prognostic information on patients with chronic lymphocytic leukemia (CLL). Although 13q deletion as the sole abnormality has been found to confer a favorable prognosis, there are little data as to whether there is a difference in prognostic value between monoallelic versus biallelic deletion of 13q....
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