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Article

Superovulation induces defective methylation in line-1 retrotransposon elements in blastocyst

18 Jul 2013

Abstract excerpt

BACKGROUND: Series of epigenetic events happen during preimplantation development. Therefore assistant reproduction techniques (ART) have the potential to disrupt epigenetic regulation during embryo development. The purpose of this study was to investigate whether defects in methylation patterns in blastocyst due to superovulation originate from abnormal expression of Dnmts. METHODS: Low- (6 IU) and high- (10 IU)...

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Share to Epigenetics and DNA Methylation
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PMID: 23866265
DOI: 10.1186/1477-7827-11-69

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