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Article

Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus.

Journal of virology - 1 Oct 2013

Min Ji-Young, Santos Celia, Fitch Adam, Twaddle Alan, Toyoda Yoshiko, DePasse Jay V, Ghedin Elodie, Subbarao Kanta

Abstract excerpt

The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host range determinant for infection of mammals. Here, we report that the E-to-K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tracts of mice and was complete by day 6 postinoculation. This mutation correlated with efficient...

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Identifiers

PMID: 23864613
DOI: 10.1128/JVI.01016-13
PMCID: PMC3807384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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