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Article

Overcoming preexisting humoral immunity to AAV using capsid decoys.

Science translational medicine - 17 Jul 2013

Mingozzi Federico, Anguela Xavier M, Pavani Giulia, Chen Yifeng, Davidson Robert J, Hui Daniel J, Yazicioglu Mustafa, Elkouby Liron, Hinderer Christian J, Faella Armida, Howard Carolann, Tai Alex, Podsakoff Gregory M, Zhou Shangzhen, Basner-Tschakarjan Etiena, Wright John Fraser, High Katherine A

Abstract excerpt

Adeno-associated virus (AAV) vectors delivered through the systemic circulation successfully transduce various target tissues in animal models. However, similar attempts in humans have been hampered by the high prevalence of neutralizing antibodies to AAV, which completely block vector transduction. We show in both mouse and nonhuman primate models that addition of empty capsid to the final vector formulation...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23863832
DOI: 10.1126/scitranslmed.3005795
PMCID: PMC4095828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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